Spindle Cell Tumors With RET Gene Fusions Exhibit a Morphologic Spectrum Akin to Tumors With NTRK Gene Fusions
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چکیده
منابع مشابه
Tumors Harbor Multiple Potentially Actionable Kinase Fusions
Infl ammatory myofi broblastic tumor (IMT) is a neoplasm that typically occurs in children. The genetic landscape of this tumor is incompletely understood and therapeutic options are limited. Although 50% of IMTs harbor anaplastic lymphoma kinase ( ALK) rearrangements, no therapeutic targets have been identifi ed in ALK-negative tumors. We report for the fi rst time that IMTs harbor other actio...
متن کاملReporter gene fusions.
Copyright: © 2006 Thomas Boulin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Both of these authors contributed equally To whom correspondence should be addressed. E-mail: [email protected] Reporter g...
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Although the BRAF V600E base substitution is an approved target for the BRAF inhibitors in melanoma, BRAF gene fusions have not been investigated as anticancer drug targets. In our study, a wide variety of tumors underwent comprehensive genomic profiling for hundreds of known cancer genes using the FoundationOne™ or FoundationOne Heme™ comprehensive genomic profiling assays. BRAF fusions involv...
متن کاملNTRK gene fusions as novel targets of cancer therapy across multiple tumour types
The tropomyosin receptor kinase (Trk) receptor family comprises 3 transmembrane proteins referred to as Trk A, B and C (TrkA, TrkB and TrkC) receptors that are encoded by the NTRK1, NTRK2 and NTRK3 genes, respectively. These receptor tyrosine kinases are expressed in human neuronal tissue and play an essential role in the physiology of development and function of the nervous system through acti...
متن کاملDetecting and visualizing gene fusions.
In recent years, gene fusions have gained significant recognition as biomarkers. They can assist treatment decisions, are seldom found in normal tissue and are detectable through Next-generation sequencing (NGS) of the transcriptome (RNA-seq). To transform the data provided by the sequencer into robust gene fusion detection several analysis steps are needed. Usually the first step is to map the...
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ژورنال
عنوان ژورنال: American Journal of Surgical Pathology
سال: 2019
ISSN: 0147-5185
DOI: 10.1097/pas.0000000000001297